30 Aug 2014

The Last #Report from @Ironorehopper


 C L O S E D 


This is the last report from Ironorehopper, after ten years of activity.

A blog must matches the needs and the interests of its author, at least, other than of its readers. For me, it is not longer this case.

During the decade I ran this blog, I met many people: true friends, some rascals, the whole bunch of lifeforms that populates the web. Sometimes it was hard to sustain the charge from those individuals, because aggressitivty is not only a characteristic of one own nasty neighbor.

I will leave here a lot of my time, spent in searching for these bad bugs and deadly events all around the world. I know now much more things than when I started and I am pleased of this.

But everything has a term, an end.

With aging, a different perspective of the events grows, and what was important when I was 35 is clearly not at the top now when I am 45.

I will not erase the blog from the host, so that readers interested in the vast archive here maintained will find eventually some interesting things.

Other blogs, sites, forums are running faster, deeper and even scarier than this old-fashioned register. Readers will find their fun elsewhere.

Sincerely, Giuseppe Michieli (IronOreHopper)

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#H7N9, #China: A human case detected in Xinjiang Uyghur Province (DoH, August 30 2014, edited)

[Source: Urumqi Department of Health, Xinjiang Uyghur Autonomous Province of China, full page in Chinese: (LINK). Automatic translation, via CIDRAP.]

#H7N9, #China: A human case detected in Xinjiang Uyghur Province [      ]

Source: Xinjiang net Posted: 2014-08-21 10:39:30    

On the 20th, H7N9 patients Lao Jin able to breathe independently. Sixth People's Hospital for autonomous H7N9 treatment team leader Song Guoping, is another small victory in the battle.

53-year-old Lao Jin infected with H7N9 avian influenza was diagnosed in August 16. Prior to this, he was diagnosed with upper respiratory tract infections, lower left lung infections, severe pneumonia.

Lao Jin, who lives in Urumqi eight Bay, welders. Three months ago, the family bought 20 chickens reared from the market, and since then, he often cleaned the house. So far there have been no chicken disease signs.

August 3, Lao Jin began to cough, sputum, body temperature quickly rose to 39.6 ℃. The "cold", near the old gold home community health service centers have been diagnosed as "upper respiratory tract infection," accepted the anti-inflammatory treatment.

On the 7th, the temperature dropped to 37.7 ℃, but the old gold and diarrhea, bloating, no significant improvement after treatment.

On the 8th, Lao Jin to the capital a top three hospital, was diagnosed with left lung infection. Despite been receiving treatment, the progression of the disease can be old gold for severe pneumonia, also appeared in septic shock and other complications.

On the 14th, giving Lao Jin intubation mechanical ventilation.

On the 16th, Lao Jin was transferred to the autonomous region Sixth People's Hospital for treatment.

Lao Jin is due before suspected cases of H7N9, to autonomous Sixth People's Hospital, the hospital started the emergency plan. To the respiratory department based H7N9 treatment group were suspected patients waiting for this.

Hospital respiratory center, severe ICU director … that admission, Lao Jin deep coma, severe pneumonia, respiratory distress, convulsions, impaired lung function, and so darling, the situation is not optimistic. Treatment group headed by …, while tissue isolation treatment, while the patient sputum sent to CDC testing.

16 afternoon, Lao Jin was diagnosed with H7N9 avian influenza infection began targeted specialist treatment.

(…)

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#Quebec #girl in isolation after showing possible #Ebola symptoms (CTV, August 30 2014)

[Source: CTV, full page: (LINK).]

Quebec girl in isolation after showing possible Ebola symptoms [      ]

CTVNews.ca Staff / Published Friday, August 29, 2014 6:23PM EDT

A Quebec girl who recently returned from a trip to Sierra Leone is under observation in a Gatineau hospital after showing possible symptoms for the Ebola virus.

(…)

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SINGLE #ANIMAL TO #HUMAN #TRANSMISSION #EVENT RESPONSIBLE FOR 2014 #EBOLA #OUTBREAK (US NIH, August 30 2014)

[Source: US National Institute of Health, full page: (LINK). Edited.]

U.S. Department of Health and Human Services, NATIONAL INSTITUTES OF HEALTH NIH News, NIH Common Fund <http://commonfund.nih.gov>

For Immediate Release: Friday, August 29, 2014

CONTACT: NIH Office of Communications, 301-496-5787, <e-mail:nihnmb@mail.nih.gov>, Edmond Byrnes, 301-451-6869, <e-mail:edmond.byrnes@nih.gov>

 

SINGLE ANIMAL TO HUMAN TRANSMISSION EVENT RESPONSIBLE FOR 2014 EBOLA OUTBREAK [      ]

NIH-funded scientist uses latest genomic technology to make discovery

Scientists used advanced genomic sequencing technology to identify a single point of infection from an animal reservoir to a human in the current Ebola outbreak in West Africa.

This research has also revealed the dynamics of how the Ebola virus has been transmitted from human to human, and traces how the genetic code of the virus is changing over time to adapt to human hosts.

Pardis Sabeti, M.D., Ph.D, a 2009 National Institutes of Health Director's New Innovator <http://commonfund.nih.gov/newinnovator/index> awardee and her team carried out the research.

"Dr. Sabeti's research shows the power of using genomic analysis to track emerging viral outbreaks," said NIH Director Francis S. Collins, M.D., Ph.D. "This ability produces valuable information that can help inform public health decisions and actions."

The 2014 Ebola outbreak is now the largest outbreak in history, with current estimates of 2,473 infections and 1350 deaths since it began in late December 2013 according to the World Health Organization. This outbreak is also the first in West Africa and the first to affect urban areas.

There are no approved drugs for Ebola virus disease, though prompt diagnosis and aggressive supportive care can improve survival. The disease is characterized by high fever, headache, body aches, intense weakness, stomach pain, and lack of appetite. This is followed by vomiting, diarrhea, rash, impaired kidney and liver function and in some cases, internal and external bleeding. 

To better understand why this outbreak is larger than previous outbreaks, Dr. Sabeti, senior associate member of the Broad Institute, Cambridge, Massachusetts, led an extensive analysis of the genetic makeup of Ebola samples from patients living in affected regions.

Joined by an international team of scientists, Dr. Sabeti used advanced technology to analyze the genetics of the Ebola samples extremely rapidly and with high levels of accuracy. Using this technology, the researchers pinpointed a single late 2013 introduction from an unspecified animal reservoir into humans.

Their study showed that the strain responsible for the West African outbreak separated from a closely related strain found in Central Africa as early as 2004, indicating movement from Central to West Africa over the span of a decade. Studying RNA changes occurring over the span of the outbreak suggests that the first human infection of the outbreak was followed by exclusive human to human transmissions.

While analyzing the genetic makeup of the Ebola samples, Dr. Sabeti and colleagues discovered a number of mutations that arose as the outbreak spread.

Some of these mutations, termed nonsynonymous mutations, alter the biological state of the virus and may allow it to continually and rapidly adapt to human immune defenses as the outbreak continues.

This feature points to the need for improved methods that will allow for close monitoring of changes in the viral genome and the impact on vaccine targets.

Such monitoring, called genomic surveillance, can provide important insights into the biology of how the Ebola virus spreads and evolves. It may also allow scientists to develop improved methods to detect infection, and point the way to new and improved drug and vaccines.

Dr. Sabeti's New Innovator Award is designed to support exceptionally creative new investigators conducting innovative and high-impact research, as part of the NIH Common Fund's High-Risk, High-Reward <http://commonfund.nih.gov/highrisk/index> program. The original focus of her research was on Lassa fever, a related but distinct hemorrhagic disease. When the Ebola outbreak began, she shifted her research focus to address this pressing challenge.

"Dr. Sabeti's New Innovator Award provided flexibility to quickly adjust her research when the 2014 Ebola outbreak began," said James M. Anderson M.D., Ph.D. director of the Division of Program Coordination, Planning and Strategic Initiatives at NIH. "This exemplifies how the High-Risk, High- Reward program allows researchers to tackle the most challenging and urgent scientific questions."

The NIH Common Fund supports a series of exceptionally high impact research programs that are broadly relevant to health and disease. Common Fund programs are designed to overcome major research barriers and pursue emerging opportunities for the benefit of the biomedical research community at large. The research products of the Common Fund programs are expected to catalyze disease-specific research supported by the NIH Institutes and Centers. To learn more about the NIH Common Fund, visit <http://commonfund.nih.gov>.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <www.nih.gov>.

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29 Aug 2014

#UN #health #agency identifies #countries at #risk for spread of #Ebola (UN, August 29 2014)

[Source: United Nations, full page: (LINK).]

UN health agency identifies countries at risk for spread of Ebola [      ]

29 August 2014

The United Nations World Health Organization (WHO) has identified six countries at risk for spread of the Ebola virus disease, adding that it is working with them to ensure that full surveillance, preparedness and response plans are in place.

“The following countries share land borders or major transportation connections with the affected countries and are therefore at risk for spread of the Ebola outbreak: Benin, Burkina Faso, Côte d’Ivoire, Guinea-Bissau, Mali, and Senegal,” the agency said in the first in a series of regular updates on the Ebola response roadmap that was issued yesterday.

“WHO and a range of partners are working with countries to ensure that full Ebola surveillance, preparedness and response plans are in place in these countries,” it added.

WHO’s Ebola Response Roadmap Situation Report 1 features up-to-date maps containing hotspots and hot zones, as well as epidemiological data showing how the outbreak is evolving over time. It also communicates what is known about the location of treatment facilities and laboratories.

It follows the release on Thursday of an Ebola response roadmap that aims to stop the transmission of Ebola virus disease (EVD) within six to nine months.

The update noted that although the numbers of new cases reported in Guinea and Sierra Leone had been relatively stable, last week saw the highest weekly increase yet in Guinea, Sierra Leone and Liberia, highlighting “the urgent need to reinforce control measures and increase capacity for case management.”

“There are serious problems with case management and infection prevention and control,” WHO said. “The situation is worsening in Liberia and Sierra Leone.”

The capacity to manage the current load of EVD cases is currently adequate in Guéckédou and in Conakry in Guinea, but in Liberia, “the capacity to cope with the increasing caseload remains dramatically low, especially in the capital, Monrovia, as well as in Bong and Nimba counties” and in Sierra Leone, there is inadequate capacity to accommodate patients in Freetown.

“Health care workers continue to be seriously affected in all countries, especially in Liberia and Nigeria,” it said.

The latest official number of Ebola cases in Guinea, Liberia, Nigeria, and Sierra Leone stands at 3,069, with over 1,552 deaths, making this the largest Ebola outbreak ever recorded, WHO said.

In an address to a meeting on Thursday of the Economic Community of West African States (ECOWAS) in Ghana, WHO called on countries to avoid taking actions that compromise the efforts to effectively respond to the ongoing Ebola outbreak in the sub-region.

Dr. David Nabarro, the UN System Coordinator for Ebola, who just completed a visit of the affected countries, is expected to brief Member States in New York on Tuesday, along with WHO Director-General Margaret Chan and Deputy Secretary-General Jan Eliasson.

In addition, WHO announced that a meeting of global experts would take place in Geneva on 5 September on potential Ebola therapies and vaccines, potential risks and benefits, uses and barriers for various options, as well as existing experimental projects.

News Tracker: past stories on this issue: Ebola caseload could exceed 20,000 in course of emergency, UN response roadmap shows

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Reversion of advanced #Ebola virus disease in nonhuman #primates with #ZMapp (Nature, abstract, edited)

[Source: Nature, full page: (LINK). Abstract, edited.]

Nature | Article near-final version

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp [      ]

Xiangguo Qiu,1, Gary Wong,1, 2, Jonathan Audet,1, 2, Alexander Bello,1, 2, Lisa Fernando,1, Judie B. Alimonti,1, Hugues Fausther-Bovendo,1, 2, Haiyan Wei,1, 3, Jenna Aviles,1, Ernie Hiatt,4, Ashley Johnson,4, Josh Morton,4, Kelsi Swope,4, Ognian Bohorov,5, Natasha Bohorova,5, Charles Goodman,5, Do Kim,5, Michael H. Pauly,5, Jesus Velasco,5, James Pettitt,6, 10, Gene G. Olinger,6, 10, Kevin Whaley,5, Bianli Xu,3, James E. Strong,1, 2, 7, Larry Zeitlin5, & Gary P. Kobinger1, 2, 8, 9, et al.

Journal name: Nature - Year published: (2014) - DOI: doi:10.1038/nature13777

Received 05 August 2014 - Accepted 21 August 2014 - Published online 29 August 2014

 

Abstract

Without an approved vaccine or treatment, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These approaches, however, have yet to end the 2014 outbreak of Ebola after its prolonged presence in West Africa. Here we show that a combination of monoclonal antibodies (ZMapp), optimized from two previous antibody cocktails, is able to rescue 100% of rhesus macaques when treatment is initiated up to 5 days post-challenge. High fever, viraemia and abnormalities in blood count and blood chemistry were evident in many animals before ZMapp intervention. Advanced disease, as indicated by elevated liver enzymes, mucosal haemorrhages and generalized petechia could be reversed, leading to full recovery. ELISA and neutralizing antibody assays indicate that ZMapp is cross-reactive with the Guinean variant of Ebola. ZMapp exceeds the efficacy of any other therapeutics described so far, and results warrant further development of this cocktail for clinical use.

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#Senegal confirms its 1st case of #Ebola, 2 #HCWs in #Liberia recovering (CP24.com, August 29 2014)

[Source: CP24, full page: (LINK).]

Senegal confirms its 1st case of Ebola [      ]

Babacar Dione, The Associated Press  - Published Friday, August 29, 2014 6:49AM EDT  - Last Updated Friday, August 29, 2014 2:50PM EDT

(…)

Because there is no known cure for Ebola, doctors can only isolate the sick and try to help their immune systems fight off the disease. But one previously untested drug has been tried in this outbreak. It's still unclear whether it's effective. On Friday, a Liberian physician's assistant and a Congolese doctor who received the ZMapp drug in Liberia were expected to be released from the hospital.

(…)

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#Nigeria monitors 160 after #Ebola kills doctor in oil city (Channel NewsAsia, August 29 2014)

[Source: Channel News Asia, full page: (LINK).]

Nigeria monitors 160 after Ebola kills doctor in oil city [      ]

Some 160 people are being medically monitored in Nigeria's oil-producing hub Port Harcourt after a doctor died from the virus, the local government said on Friday (Aug 29).

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#H3N2v Influenza Virus Infection in #Ohio (@CDCgov, FluView, August 29 2014)

[Source: US Centers for Disease Control and Prevention (CDC), FluView, full page: (LINK). Extract.]

(…)

Novel Influenza A Viruses [H3N2v] [      ]

One new human infection with a novel influenza A virus was reported by Ohio.

The person was infected with an influenza A (H3N2) variant (H3N2v) virus and was not hospitalized as a result of their illness.

No ongoing human-to-human transmission has been identified and the case reported close contact with swine in the week prior to illness onset.

Public health and agriculture officials are investigating the extent of disease among humans and swine and no increases in influenza-like illness in the community have been reported.

Genetic sequencing of the H3N2v virus conducted at CDC showed that this virus has the nucleoprotein (NP) and matrix (M) gene from the 2009 H1N1 virus, and was similar to the H3N2v virus identified previously this summer.

A total of two H3N2v cases have been reported in 2014 and are not epidemiologically linked.

Early identification and investigation of human infections with novel influenza A viruses is critical in order to evaluate the extent of the outbreak and possible human-to-human transmission.

Additional information on influenza in swine, variant influenza infection in humans, and strategies to interact safely with livestock can be found at http://www.cdc.gov/flu/swineflu/h3n2v-cases.htm.

(…)

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#Macau, 4 indivíduos provenientes dos cinco países afectados com vírus #Ébola foram avaliados pelos Serviços de Saúde, um dos quais necessitou de ser clinicamente vigiado (DoH, August 29 2014)

[Source: Department of Health, Macau PRC SAR, full page: (LINK).]

4 indivíduos provenientes dos cinco países afectados com vírus Ébola foram avaliados pelos Serviços de Saúde, um dos quais necessitou de ser clinicamente vigiado [      ]

2014-08-29 22:27:00 - Fonte : Serviços de Saúde

Os Serviços de Saúde e o Corpo de Segurança da PSP estão activamente a colaborar no âmbito das medidas de prevenção implementadas para impedir a propagação do vírus Ébola. No âmbito da vigilância que está a decorrer nas areas de fronteira foram registados nas últimas 24 horas - entre as 17:00 horas da quinta-feira (28 de Agosto) e as 17:00 horas da sexta-feira (29 de Agosto) – a entrada no território da RAEM de quatro (4) indivíduos provenientes da Guiné Conacri, da Libéria, de Serra Leoa, da Nigéria e da República Democrática do Congo.

Depois da avaliação de saúde efectuada a estes indivíduos, verificou-se que os três (3) indivíduos não apresentavam sintomas relacionados com contaminação com o vírus Ébola e pelo facto de estarem há mais de 21 dias (período máximo de incubação do vírus Ébola) fora do seu país não necessitaram de ser submetidos à vigilância sanitária.

No entanto um homem da Serra Leoa que declarou sair deste país no dia 18 de Agosto, ou seja, esteve numa região infectada dentro de 21 dias, período máximo de incubação do vírus Ébola, e apesar de não apresentar nenhum sintoma relativo à doença por vírus Ébola na sua entrada em Macau, os Serviços de Saúde procederão diariamente à viligância sanitária.

Os Serviços de Saúde reiteram que atendendo à gravidade da epidemia de vírus Ébola que está a ocorrer em algumas regiões da África Ocidental, os Serviços de Saúde têm prestado atenção ao seu desenvolvimento. Em conformidade com as orientações da Organização Mundial de Saúde, os Serviços de Saúde já estabeleceram o necessário plano de contingência, adaptável conforme o desenvolvimento epidemiológico, a fim de reduzir o mais possível os riscos de ocorrência do surto em Macau. Aliás a RAEM possui capacidade para lidar com os casos suspeitos do vírus Ébola que possam surgir, e os S.S. divulgarão mensagens de prevenção e protecção de forma oportuna aos cidadãos e todos os sectores sociais.

Os Serviços de Saúde apelam mais uma vez aos cidadãos que, antes de deslocarem à Guiné Conacri, à Libéria, à Serra Leoa, ao Lagos da Nigéria e à República Democrática do Congo, devem proceder à avaliação cuidadosa das reais necessidade, cancelando ou adiando as viagens desnecessárias. Em caso de permanecerem nas regiões afectadas, devem prestar atenção à higiene individual e ambiental, lavar com frequência as mãos seguindo os procedimentos correctos, evitando ao máximo ter contacto com animais vivos e mortos, não comer carne de origem de animais selvagens, consumir as frutas e vegetais descascados e limpos. Caso não seja estritamente necessário devem abster-se de entrar em hospitais ou efectuar visitas a famílias que possam ser consideradas de risco. Ao mesmo tempo, evite contactar com o doente suspeito e o seu sangue ou fluidos corporais, assim como com os produtos que pode ter contacto com o sangue ou fluidos corporais do doente suspeito; caso contacte inadvertidamente com o sangue ou fluidos de pessoas doentes, lave de imediato as mãos e contacte com um médico.

-- Fim --

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