2 Oct 2014

#Ebola in #America spooks #US #markets (The Independent, October 2 2014)

[Source: The Independent, full page: (LINK).]

Ebola in America spooks US markets [      ]

Shares tumbled across Wall Street as news that a patient had been diagnosed with Ebola in Texas spooked investors and left airline shares in particular under pressure.

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#US to Increase #Production of the #Ebola Drug #ZMapp, but May Not Meet Demand (NYT Health, October 2 2014)

[Source: The New York Times, full page: (LINK).]

U.S. to Increase Production of the Ebola Drug ZMapp, but May Not Meet Demand [      ]

By ANDREW POLLACK  

Despite the new efforts, supplies of the drug, ZMapp, are expected to be limited to hundreds or thousands of treatment courses by early next year, which would not be nearly enough if the epidemic continues to spiral out of control.

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Man with #Ebola virus flew on three #flights to #US (Telegraph, October 2 2014)

[Source: Telegraph, full page: (LINK).]

Man with Ebola virus flew on three flights to US [      ]

Federal officials say other passengers on the flights with … [the patient] are at no risk of infection because the man had no symptoms at the time of his trip.

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#Venezuela, Salud Miranda: El #chikungunya afecta especialmente a la población económicamente activa (El Nacional, October 2 2014)

[Source: El Nacional, full page: (LINK).]

Salud Miranda: El chikungunya afecta especialmente a la población económicamente activa [      ]

De acuerdo con el boletín epidemiológico de la semana 38, los casos sospechosos pasaron de 110 en la medición anterior a 181 en la presente  …

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#Hawaii #patient in isolation over #Ebola concerns (CBS News, October 2 2014)

[Source: CBS, full page: (LINK).]

Hawaii patient in isolation over Ebola concerns [      ]

Honolulu hospital "taking all the precautions that are necessary to keep people safe," official says …

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#Ebola. Les #USA dans la crainte d'autres cas sur leur territoire (@ouestfrancefr, October 2 2014)

[Source: Ouest France, full page: (LINK).]

Ebola. Les USA dans la crainte d'autres cas sur leur territoire [      ]

Le premier patient porteur du virus Ebola à avoir été identifié aux Etats-Unis, un Libérien, a pu contaminer plusieurs personnes de son entourage, dont des enfants, après l'échec du personnel médical d'un hôpital texan à faire le bon diagnostic lors de sa première visite aux urgences.Les proches...

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#Ebola In The #ER: The #Importance Of Taking A #Travel #History (Forbes, October 2 2014)

[Source: Forbes, full page: (LINK).]

Ebola In The ER: The Importance Of Taking A Travel History [      ]

When … [the patient] went to visit the emergency department (ED) with fever and abdominal pain on September 26, the fact that he recently arrived from Liberia was a key element in his initial contact with the Texas Health Presbyterian Hospital System in Dallas.

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#Saudi Arabia reported a new #MERS-CoV case in the last 24 hours; an earlier case died (@SaudiMOH, October 2 2014, edited)

[Source: Saudi Arabia Ministry of Health, full page: (LINK). Edited.]

#Saudi Arabia reported a new #MERS-CoV case in the last 24 hours; an earlier case died [      ][      ]

10/1/2014

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New Cases:

  1. man, 65 years old, Saudi National, resident in Jubail, currently hospitalized in intensive care unit, with pre-existing medical condition and history of contacts with camels.

Earlier reported cases discharged from hospital:

  • No reports

Deaths in previously announced cases:

  1. man, 43 years old, Saudi National, resident in Taif, with pre-existing medical condition.

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بيان-7ذي-الحجه-1.jpg

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بيان-7ذي-الحجه-3.jpg

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#Simvastatin in the Acute Respiratory Distress Syndrome [#ARDS] (N Engl J Med., abstract, edited)

[Source: The New England Journal of Medicine, full page: (LINK). Abstract, edited.]

Original Article

Simvastatin in the Acute Respiratory Distress Syndrome [      ]

Daniel F. McAuley, M.D., John G. Laffey, M.D., Cecilia M. O'Kane, Ph.D., Gavin D. Perkins, M.D., Brian Mullan, M.B., T. John Trinder, M.D., Paul Johnston, M.B., Philip A. Hopkins, Ph.D., Andrew J. Johnston, M.D., Cliona McDowell, M.Sc., Christine McNally, B.A., and the HARP-2 Investigators, for the Irish Critical Care Trials Group

September 30, 2014DOI: 10.1056/NEJMoa1403285

 

Abstract

Background

Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that treatment with simvastatin would improve clinical outcomes in patients with ARDS.

Methods

In this multicenter, double-blind clinical trial, we randomly assigned (in a 1:1 ratio) patients with an onset of ARDS within the previous 48 hours to receive enteral simvastatin at a dose of 80 mg or placebo once daily for a maximum of 28 days. The primary outcome was the number of ventilator-free days to day 28. Secondary outcomes included the number of days free of nonpulmonary organ failure to day 28, mortality at 28 days, and safety.

Results

The study recruited 540 patients, with 259 patients assigned to simvastatin and 281 to placebo. The groups were well matched with respect to demographic and baseline physiological variables. There was no significant difference between the study groups in the mean (±SD) number of ventilator-free days (12.6±9.9 with simvastatin and 11.5±10.4 with placebo, P=0.21) or days free of nonpulmonary organ failure (19.4±11.1 and 17.8±11.7, respectively; P=0.11) or in mortality at 28 days (22.0% and 26.8%, respectively; P=0.23). There was no significant difference between the two groups in the incidence of serious adverse events related to the study drug.

Conclusions

Simvastatin therapy, although safe and associated with minimal adverse effects, did not improve clinical outcomes in patients with ARDS. (Funded by the U.K. National Institute for Health Research Efficacy and Mechanism Evaluation Programme and others; HARP-2 Current Controlled Trials number, ISRCTN88244364.)

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1 Oct 2014

Peter #Piot, #Ebola Co- #Discoverer: ‘This Was an Avoidable #Catastrophe’ (@TIME, October 1 2014)

[Source: TIME, full page: (LINK).]

Ebola Co-Discoverer: ‘This Was an Avoidable Catastrophe’ [      ]

The news from Dallas that the first Ebola case outside of Africa has been diagnosed on U.S. soil is a stark reminder that epidemics on the other side of the world are a threat to us all. No epidemic is just local.

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