22 Dec 2014

#HK, #CHP notified of seven additional #human #cases of #avian #influenza A(#H7N9) in #China Mainland (December 22 2014)

[Source: Centre for Health Protection, Hong Kong PRC SAR, full page: (LINK). Edited.]

CHP notified of seven additional human cases of avian influenza A(H7N9) in Mainland  [      ]

The Centre for Health Protection (CHP) of the Department of Health (DH) today (December 22) received notification of seven additional human cases of avian influenza A(H7N9) in Xinjiang Uyghur Autonomous Region (Xinjiang) (four cases), Zhejiang (two cases) and Jiangsu (one case) from the National Health and Family Planning Commission.

The patients comprise five men and two women aged from 36 to 81.

Four of them (three from Xinjiang and one from Jiangsu) died while two of them (one from Xinjiang and one from Zhejiang) are currently in serious condition.

The remaining case from Zhejiang is now in mild condition and did not require hospitalisation.

To date, 454 human cases of avian influenza A(H7N9) have been confirmed in the Mainland in:

  1. Zhejiang (141 cases),
  2. Guangdong (111 cases),
  3. Jiangsu (59 cases),
  4. Shanghai (42 cases),
  5. Hunan (24 cases),
  6. Fujian (23 cases),
  7. Anhui (17 cases),
  8. Jiangxi (eight cases),
  9. Xinjiang (eight cases),
  10. Beijing (five cases),
  11. Shandong (five cases),
  12. Henan (four cases),
  13. Guangxi (three cases),
  14. Jilin (two cases),
  15. Guizhou (one case) and
  16. Hebei (one case).

"Locally, we will remain vigilant and work closely with the World Health Organization and relevant health authorities to monitor the latest developments," a spokesman for the DH said.

"In view of cases confirmed on the Mainland, members of the public should maintain good personal, food and environmental hygiene at all times during travel," the spokesman said.

"All boundary control points have implemented disease prevention and control measures. Thermal imaging systems are in place for body temperature checks of inbound travellers. Suspected cases will be immediately referred to public hospitals for follow-up investigation," the spokesman added.

Regarding health education for travellers, the display of posters and broadcasting of health messages in departure and arrival halls, environmental health inspection and provision of regular updates to the travel industry via meetings and correspondence are proceeding.

Travellers, especially those returning from avian influenza-affected areas with fever or respiratory symptoms, should immediately wear masks, seek medical attention and reveal their travel history to doctors. Health-care professionals should pay special attention to patients who might have had contact with poultry, birds or their droppings in affected areas.

The public should remain vigilant and take heed of the advice against avian influenza below:

  • Do not visit live poultry markets and farms. Avoid contact with poultry, birds and their droppings;
  • If contact has been made, thoroughly wash hands with soap;
  • Avoid entering areas where poultry may be slaughtered and contact with surfaces which might be contaminated by droppings of poultry or other animals;
  • Poultry and eggs should be thoroughly cooked before eating;
  • Wash hands frequently with soap, especially before touching the mouth, nose or eyes, handling food or eating; after going to the toilet or touching public installations or equipment (including escalator handrails, elevator control panels and door knobs); and when hands are dirtied by respiratory secretions after coughing or sneezing;
  • Cover the nose and mouth while sneezing or coughing, hold the spit with a tissue and put it into a covered dustbin;
  • Avoid crowded places and contact with fever patients; and
  • Wear masks when respiratory symptoms develop or when taking care of fever patients.

The public may visit the avian influenza page of the CHP of the DH (www.chp.gov.hk/en/view_content/24244.html) for more information on avian influenza. The updated information of affected areas can be found on the following webpage: www.chp.gov.hk/files/pdf/global_statistics_avian_influenza_e.pdf.

Ends/Monday, December 22, 2014

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21 Dec 2014

#Restrictions lifted on moving #poultry in #UK after [#H5N8] #bird #flu cull (@Guardian, December 21 2014)

[Source: The Guardian, full page: (LINK).]

Restrictions lifted on moving poultry in UK after bird flu cull [      ]

by Press Association  

Restrictions imposed on the movement of poultry after an outbreak of bird flu have been lifted, the government has said. Some 6,000 ducks were culled on a farm at Nafferton, near Driffield, east Yorkshire, following the identification of “highly pathogenic” H5N8 bird flu last month.

(…)

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#Saudi Arabia reported no new #MERS-CoV cases in the last 24 hours (@SaudiMOH, December 21 2014, edited)

[Source: Saudi Arabia Ministry of Health, full page: (LINK). Edited.]

#Saudi Arabia reported no new #MERS-CoV cases in the last 24 hours [      ][      ]

12/21/2014

________

New Cases:

  • No reports

Earlier reported cases discharged from hospital:

  • No reports

Deaths among previously announced cases:

  • No reports

_______

21-12-2014-1.jpg

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21-12-2014-3.jpg

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Fused-ring structure of decahydroisoquinolin as a novel scaffold for #SARS 3CL #protease #inhibitors (Science Direct, abstract, edited)

[Source: Science Direct, full page: (LINK). Abstract, edited.]

Bioorganic & Medicinal Chemistry / Available online 20 December 2014 / In Press, Accepted Manuscript

Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors [      ]

Yasuhiro Shimamoto a, Yasunao Hattori a, Kazuya Kobayashi a, Kenta Teruya b, Akira Sanjoh c, Atsushi Nakagawa d, Eiki Yamashita d, Kenichi Akaji a

doi:10.1016/j.bmc.2014.12.028

 

Abstract

The design and evaluation of a novel decahydroisoquinolin scaffold as an inhibitor for severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CLpro) are described. Focusing on hydrophobic interactions at the S2 site, the decahydroisoquinolin scaffold was designed by connecting the P2 site cyclohexyl group of the substrate-based inhibitor to the main-chain at the α−nitrogen atom of the P2 position via a methylene linker. Starting from a cyclohexene enantiomer obtained by salt resolution, trans-decahydroisoquinolin derivatives were synthesized. All decahydroisoquinolin inhibitors synthesized showed moderate but clear inhibitory activities for SARS 3CLpro, which confirmed the fused ring structure of the decahydroisoquinolin functions as a novel scaffold for SARS 3CLpro inhibitor. X-ray crystallographic analyses of the SARS 3CLpro in a complex with the decahydroisoquinolin inhibitor revealed the expected interactions at the S1 and S2 sites, as well as additional interactions at the N-substituent of the inhibitor.

 

Graphical abstract

Full-size image (15 K)

_______

 

Keywords: SARS 3CL protease; Inhibitor; Decahydroisoquinolin; Hydrophobic interaction

Corresponding author. Address: Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan. Tel./fax: +81-75-595-4635.

Copyright © 2014 Published by Elsevier Ltd.

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Development of #Vaccines for #prevention of #Ebola virus #infection. (Microbes Infect., abstract, edited)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Microbes Infect. 2014 Dec 16. pii: S1286-4579(14)00312-8. doi: 10.1016/j.micinf.2014.12.004. [Epub ahead of print]

Development of Vaccines for prevention of Ebola virus infection. [      ]

Ye L1, Yang C2.

Author information: 1Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America. 2Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America. Electronic address: chyang@emory.edu.

 

Abstract

Ebola virus infection causes severe hemorrhagic fevers with high fatality rates up to 90% in humans, for which no effective treatment is currently available. The ongoing Ebola outbreak in West Africa that has caused over 14000 human infections and over 5000 deaths underscores its serious threat to the public health. While licensed vaccines against Ebola virus infection is still not available, a number of vaccine approaches have been developed and shown to protect against lethal Ebola virus infection in animal models. This review aims to summarize the advancement of different strategies for Ebola vaccine development with a focus on the discussion of their protective efficacies and possible limitations. In addition, the development of animal models for efficacy evaluation of Ebola vaccines and the mechanism of immune protection against Ebola virus infection are also discussed.

Copyright © 2014. Published by Elsevier Masson SAS.

KEYWORDS: Ebola; animal model; immune response; vaccine

PMID: 25526819 [PubMed - as supplied by publisher]

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20 Dec 2014

#Chicago #Patient Being Monitored for #Ebola Symptoms Discharged (NBC Chicago, December 20 2014)

[Source: NBC, full page: (LINK).]

Chicago Patient Being Monitored for Ebola Symptoms Discharged [   !   ]

Saturday, Dec 20, 2014 • Updated at 1:36 PM CST

Medical personnel at the University of Chicago Medical Center who were monitoring a child to rule out an Ebola diagnosis say the child has been discharged.

(…)

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#Saudi Arabia reported no new #MERS-CoV cases in the last 24 hours (@SaudiMOH, December 20 2014, edited)

[Source: Saudi Arabia Ministry of Health, full page: (LINK). Edited.]

#Saudi Arabia reported no new #MERS-CoV cases in the last 24 hours [      ][      ]

12/20/2014

_______

New Cases:

  • No reports

Earlier reported cases discharged from hospital:

  • No reports

Deaths among previously announced cases:

  • No reports

_______

_______

Statistics - MOH: 'No New Corona Cases Recorded'

Full- #Genome #Sequence of a #Reassortant #H1N2 #Influenza A Virus Isolated from #Pigs in #Brazil (Genome Announc., abstract, edited)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Genome Announc. 2014 Dec 18;2(6). pii: e01319-14. doi: 10.1128/genomeA.01319-14.

Full-Genome Sequence of a Reassortant H1N2 Influenza A Virus Isolated from Pigs in Brazil. [      ]

Schmidt C1, Cibulski SP2, Muterle Varela AP2, Mengue Scheffer C2, Wendlant A2, Quoos Mayer F2, Lopes de Almeida L3, Franco AC3, Roehe PM1.

Author information: 1candy.schmidt@hotmail.com proehe@gmail.com. 2Fepagro Animal Health-Institute of Veterinary Research Desidério Finamor (IPVDF), Eldorado do Sul, Rio Grande do Sul, Brazil. 3Virology Laboratory, Department of Microbiology, Immunology and Parasitology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil.

 

Abstract

In this study, the full-genome sequence of a reassortant H1N2 swine influenza virus is reported. The isolate has the hemagglutinin (HA) and neuraminidase (NA) genes from human lineage (H1-δ cluster and N2), and the internal genes (polymerase basic 1 [PB1], polymerase basic 2 [PB2], polymerase acidic [PA], nucleoprotein [NP], matrix [M], and nonstructural [NS]) are derived from human 2009 pandemic H1N1 (H1N1pdm09) virus.

Copyright © 2014 Schmidt et al.

PMID: 25523775 [PubMed]

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With strengthened #guidelines for #health care #workers, the #CDC ups its game against the deadly #Ebola virus (ED Manag., abstract, edited)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

ED Manag. 2014 Dec;26(12):133-6.

With strengthened guidelines for health care workers, the CDC ups its game against the deadly Ebola virus. [      ]

[No authors listed]

 

Abstract

Informed by the cases of two nurses who contracted Ebola virus disease (EVD) while caring for a patient with the disease in Dallas, TX, the Centers for Disease Control and Prevention (CDC) in Atlanta, GA, has unveiled strengthened guidance for health care workers. Further, nursing organizations are pledging to work together to identify gaps and make system-level improvements to protect both patients and caregivers. The CDC's new recommendations emphasize rigorous training for health care workers in how to put on and take off personal protective equipment (PPE), and they state that this activity should always be carefully supervised by a monitor. The guidance also states that health care workers should use either an N-95' respirator mask or a powered air purifying respirator (PAPR) when they are providing care to a patient with Ebola. Experts stress that the new guidance does not change the fundamental issue that Ebola is transmitted through contact with infectious substances from patients. Nursing organizations are pledging to work together to identify problems and improve safety for both caregivers and patients.

PMID: 25522493 [PubMed - in process]

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#Hospitals prepare #plans, drill staff to ensure that potential #Ebola #patients are identified, isolated, and managed safely (ED Manag., abstract, edited)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

ED Manag. 2014 Dec;26(12):138-41.

Hospitals prepare plans, drill staff to ensure that potential Ebola patients are identified, isolated, and managed safely. [      ]

[No authors listed]

 

Abstract

Hospitals around the country have stepped up their efforts to train staff and implement procedures to ensure the safe identification and management of any patients with signs of Ebola virus disease (EVD). Ronald Reagan UCLA Medical Center in Los Angeles, CA, held an "Ebola preparedness exercise" to give staff an opportunity to walk through the hospital's protocol for handling a simulated patient with EVD. The University of Alabama at Birmingham (UAB) Medical Center has held similar exercises, and is now holding twice-weekly meetings of its leadership team to make sure that all new developments in the Ebola outbreak are communicated. UCLA Medical Center has prepared PPE kits based on the practices developed at Emory University Hospital, which has thus far had the most experience in this country in caring for patients with EVD. The UCLA Health System has adjusted its medical record system so that a red flag is placed on the electronic medical record [EMR] of any patient who has recently traveled to a high-risk area. UAB Medical Center has incorporated what had been a paper-and-pencil screening tool for EVD into its electronic medical record. Training on PPE as well as EVD screening is being provided to first-responders and 911 call center dispatchers in the UAB system.

PMID: 25522495 [PubMed - in process]

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